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The Warner siblings, Yakko and Wakko, and Dot, have a great time wreaking havoc and mayhem in the lives of everyone they meet. After returning to their beloved home, the Warner Bros. Water Tower, the Animaniacs waste no time in causing chaos and comic confusion as they run loose through the studio and beyond, turning the world into their personal playground. Joining Yakko, Wakko and Dot are fan-favorite characters Pinky and the Brain, continuing their quest for world domination.