The prize: ending the Apocalypse. The price: Sam's life. Season 5's horrific finale left Dean alone, as Sam descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family with Lisa and her son Ben. Then, mysteriously, Sam reappears, drawing Dean back into the old life. But Sam's a different man too. He's returned without his soul. How the Winchesters confront this greatest challenge yet to their powerful bond is the troubled heart - and soul - of the profound and thrilling 22-Episode Season 6. As the brothers struggle to reunite, they must also battle deadly supernatural forces. Demons. Angels. Vampires. Shapeshifters. And a terrifying new foe called the Mother of All.
First aired: 2010-09-24